Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents.

@article{Backhauss1992ExtractOK,
  title={Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents.},
  author={C Backhauss and Josef Krieglstein},
  journal={European journal of pharmacology},
  year={1992},
  volume={215 2-3},
  pages={265-9}
}
The purpose of the present study was to test whether kava extract and its constituents kawain, dihydrokawain, methysticin, dihydromethysticin and yangonin provide protection against ischemic brain damage. To this end, we used a model of focal cerebral ischemia in mice and rats. Ischemia was induced by microbipolar coagulation of the left middle cerebral artery (MCA). To quantify the size of the lesion in mice, the area of the infarct on the brain surface was assessed planimetrically 48 h after… CONTINUE READING