Extract of Cassiae Semen and its major compound inhibit S100b-induced TGF-beta1 and fibronectin expression in mouse glomerular mesangial cells.

@article{Jung2010ExtractOC,
  title={Extract of Cassiae Semen and its major compound inhibit S100b-induced TGF-beta1 and fibronectin expression in mouse glomerular mesangial cells.},
  author={Dong Ho Jung and Young Han Kim and Nan Hee Kim and Jun Kyong Lee and Dae Sik Jang and Jin Sook Kim},
  journal={European journal of pharmacology},
  year={2010},
  volume={641 1},
  pages={7-14}
}
Non-enzymatic glycation reactions between reducing sugar and free reactive amino groups of protein lead to the formation of advanced glycation end products, which increase under conditions of aging or diabetes. A previous study showed that extracts of Cassiae Semen (CS), the seed of Cassia tora, had inhibitory activity on advanced glycation end products formation in vitro. To examine the pharmacological effects of a butanol-soluble extract of CS under conditions of diabetic nephropathy, we… CONTINUE READING

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