Extracorporeal photopheresis (photochemotherapy) in the treatment of acute and chronic graft versus host disease: immunological mechanisms and the results from clinical studies

@article{Bruserud2014ExtracorporealP,
  title={Extracorporeal photopheresis (photochemotherapy) in the treatment of acute and chronic graft versus host disease: immunological mechanisms and the results from clinical studies},
  author={\Oystein Bruserud and T H A Tvedt and Petter Quist Paulsen and Aymen Bushra Ahmed and Tobias Gedde-Dahl and Geir Erland Tj\onnfjord and Heidi Sl{\aa}stad and Dag Heldal and H{\aa}kon Reikvam},
  journal={Cancer Immunology, Immunotherapy},
  year={2014},
  volume={63},
  pages={757-777}
}
Extracorporeal photopheresis (ECP) is an immunomodulatory alternative for treatment of graft versus host disease (GVHD). The blood is then separated into its various components through apheresis; buffy coat cells are thereafter treated with 8-methoxypsoralen before exposure to ultraviolet light and finally reinfused into the patient. There is a general agreement that this treatment has an anti-GVHD effect, but the mechanisms of action behind this effect are only partly understood. However… CONTINUE READING
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