Extracorporeal membrane oxygenation support of donor abdominal organs in non‐heart‐beating donors

@article{Ko2000ExtracorporealMO,
  title={Extracorporeal membrane oxygenation support of donor abdominal organs in non‐heart‐beating donors},
  author={Wen Je Ko and Yih-Sharng Chen and Pi‐Ru Tsai and Po-Huang Lee},
  journal={Clinical Transplantation},
  year={2000},
  volume={14}
}
Both family consent and legal consent were required for organ/tissue donation from non‐heart‐beating donors (NHBD) in Taiwan. A district attorney had to come to the bedside to confirm the donor's asystole, confirm the family consent, and complete some legal documents before a legal consent was issued for organ donation. The resultant warm ischemic time would be unpredictably long and in fact precluded the organ donation from NHBD in Taiwan. We developed a method of using extracorporeal membrane… 

Expanding the donor pool: use of renal transplants from non‐heart‐beating donors supported with extracorporeal membrane oxygenation

The long‐term allograft survival and function of kidneys from NHBDs supported by ECMO, HBD, and LD did not differ significantly and long ECMO running time tended to delay graft function.

The use of in-situ normothermic extracorporeal perfusion and leukocyte depletion for resuscitation of human donor kidneys

Treatment of ischemically damaged kidneys by normothermic extracorporeal perfusion, with leukocyte depletion before procurement, seems to be a challenging protocol and demands further study.

Heart-Beating and Non-Heart-Beating Donors

In the clinical setting, NEC MO has been demonstrated to offer the possibility to obtain good quality grafts for transplant both in controlled and in uncontrolled DCD, and in some countries ECMO has been used to support brain death (BD) multiorgan donors in case in which it is not possible to complete death assessment for cardiac or respiratory failure.

Development of a preclinical model of donation after circulatory determination of death for translational application

The authors' ANOR model is the closest to clinical conditions reported in the literature and will allow the study of the systemic and abdominal organ impact of this technique, and will permit the determination of new biomarkers and protocols to improve DCD donor management.

In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival

  • C. WatsonFiona Hunt G. Oniscu
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019
Livers from controlled donation after circulatory death (DCD) donors suffer a higher incidence of nonfunction, poor function, and ischemic cholangiopathy. In situ normothermic regional perfusion

Lung Physiology During ECS Resuscitation of DCD Donors Followed by In Situ Assessment of Lung Function

Extracorporeal cardiopulmonary support of DCD donors is feasible and allows for assessment of function before procurement, and pulmonary congestion does not cause pulmonary congestion, and the lungs retain adequate function for transplantation.

Abdominal regional in-situ perfusion in donation after circulatory determination of death donors

ARP is an important form of donor maintenance that helps improve DCD organ viability and may help expand the applicability of transplantation using organs arising through this process.

The use of extracorporeal membranous oxygenation in donors after cardiac death

The use of ECMO in donors after cardio-circulatory death should be encouraged and further developed to better define the optimal conditions of the technique, which will help to limit or even repair the injuries, induced by warm ischaemia.

Non-heartbeating donation of kidneys for transplantation

The proportion of NHB donor kidneys in the total pool of postmortem kidneys differs considerably between countries, and in The Netherlands, the proportion is nearly 50%.
...

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