Extracorporeal membrane oxygenation induces short-term loss of high-molecular-weight von Willebrand factor multimers.

@article{Tauber2015ExtracorporealMO,
  title={Extracorporeal membrane oxygenation induces short-term loss of high-molecular-weight von Willebrand factor multimers.},
  author={Helmuth Tauber and Helmut Ott and Werner Streif and Guenter Weigel and Lorin Loacker and Josef Fritz and Anneliese Heinz and Corinna Velik-Salchner},
  journal={Anesthesia and analgesia},
  year={2015},
  volume={120 4},
  pages={730-6}
}
BACKGROUND High-molecular-weight (HMW) von Willebrand factor (vWF) multimers are crucial for primary hemostasis. Increased shear stress from ventricular assist devices can provoke premature degradation of HMW vWF multimers. Whether similar loss of vWF multimers occurs during extracorporeal membrane oxygenation (ECMO) is not clear. METHODS We conducted a prospective observational study in a clinical cohort of patients who required ECMO for intractable cardiac and/or respiratory failure. The… CONTINUE READING
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