Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database

  title={Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database},
  author={Thomas V Brogan and Ravi R. Thiagarajan and Peter T. Rycus and Robert H. Bartlett and Susan L Bratton},
  journal={Intensive Care Medicine},
ObjectiveTo evaluate clinical and treatment factors for patients recorded in the Extracorporeal Life Support Organization (ELSO) registry and survival of adult extracorporeal membrane oxygenation (ECMO) respiratory failure patients.Design and patientsRetrospective case review of the ELSO registry from 1986–2006. Data were analyzed separately for the entire time period and the most recent years (2002–2006).ResultsOf 1,473 patients, 50% survived to discharge. Median age was 34 years. Most… 
Extracorporeal Membrane Oxygenation for Respiratory Failure in the Elderly: A Review of the Extracorporeal Life Support Organization Registry
Age should not be a firm contraindication for the use of ECMO in older patients but should be considered on a case-by-case basis, given the noted survival in elderly patients treated with ECMO.
Discharge outcome in adults treated with extracorporeal membrane oxygenation.
Patients with respiratory indications for ECMO experienced better survival than did cardiac patients, and increasing age was associated with poor outcome.
Extracorporeal membrane oxygenation for pediatric respiratory failure: Survival and predictors of mortality*
Although the survival of pediatric patients with acute respiratory failure treated with extracorporeal membrane oxygenation has not changed, this treatment is currently offered to increasingly medically complex patients.
Predicting Survival of Adult Respiratory Failure Patients Receiving Prolonged (≥14 Days) Extracorporeal Membrane Oxygenation
Findings suggest that reducing ECMO-related complications will improve survival, and identify predictors of mortality in prolonged ECMO patients, and inclusion of ECMO complications in a new predictive model improved discrimination.
Survival predictors in acute respiratory distress syndrome with extracorporeal membrane oxygenation.
Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study
Among neurologic, vascular, infectious and bleeding events that occurred on ECMO, bleeding was the most frequent and had a significant impact on mortality, and interventions that reduce these complications may improve outcome.
Outcome of Adult Respiratory Failure Patients Receiving Prolonged (≥14 Days) ECMO
Prolonged ECMO use for adult respiratory failure was associated with a lower hospital survival rate, compared with prior reported survival rates of short duration ECMO, and increasing ECMO duration did not alter the survival fraction in the 1989 to 2013 study cohort.
Survival Predictors for Severe ARDS Patients Treated with Extracorporeal Membrane Oxygenation: A Retrospective Study in China
For severe ARDS patients treated with ECMO, barotrauma prior to ECMO and underlying lung disease may be major predictors of ARDS prognosis based on multivariate analysis.
Extracorporeal Membrane Oxygenation (ecmo) In Adults In The United States From 2006-2011
ECMO as a therapeutic modality should be given consideration in critically ill patients with reversible cardio-respiratory collapse with no significant changes in survival rates or hospitalization costs from 2006 to 2011.
Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support
AKD stage is an independent predictor of survival in patients on ECMO support, and Cox proportional hazards model was used to determine the prognostic factors associated with survival.


National experience with extracorporeal membrane oxygenation for newborn respiratory failure. Data from 715 cases.
The results indicate that ECMO and lung rest is appropriate and successful treatment for newborn respiratory failure unresponsive to other means of management, and that almost all respiratory failure is reversible in near-term neonates.
The impact of extracorporeal membrane oxygenation on survival in pediatric patients with acute respiratory failure. Pediatric Critical Care Study Group.
The use of ECMO was associated with an improved survival in pediatric patients with respiratory failure and the lack of association of outcome with treatment in the ECMO-capable hospital or with another tertiary technology suggests that ECMO itself was responsible for the improved outcome.
Extracorporeal membrane oxygenation for adult respiratory failure.
Survival with ECMO is 66% for adults with severe respiratory failure, and ECMO should be considered in patients who remain hypoxic despite maximal positive pressure ventilation.
Extracorporeal life support for 100 adult patients with severe respiratory failure.
Modeling of variables during ECLS showed that no mechanical complications were independent predictors of outcome, and the only patient-related complications associated with outcome were the presence of renal failure and significant surgical site bleeding.
Early experience with adult extracorporeal membrane oxygenation in the modern era.
Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study.
Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which
Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study.
It is concluded that ECMO can support respiratory gas exchange but did not increase the probability of long-term survival in patients with severe ARF.
High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation
A high survival rate can be obtained in adult patients with severe ARDS using ECMO and pressure-supported ventilation with minimal sedation, and surgical complications are amenable to surgical treatment during ECMO.
Treatment of severe acute respiratory distress syndrome: role of extracorporeal gas exchange
ECMO treatment does not predict mortality in patients with most severe ARDS, as expected.
High survival rate in 122 ARDS patients managed according to a clinical algorithm including extracorporeal membrane oxygenation
It is concluded that patients with ARDS can be successfully treated with the clinical algorithm and high survival rates can be achieved.