Extracorporeal management of valproic acid overdose: a large regional experience.

  title={Extracorporeal management of valproic acid overdose: a large regional experience.},
  author={Sheldon Michael Singh and Brendan B McCormick and Stefan Mustata and Margaret Thompson and G V Ramesh Prasad},
  journal={Journal of nephrology},
  volume={17 1},
BACKGROUND Valproic acid intoxication is common in North America. Although extra-corporeal therapy has been proposed as beneficial in managing significant exposures, evidence to support its use is limited to isolated case reports. A systematic review has not been performed. METHODS All cases of valproic acid overdose in Ontario, Canada, reported to the Hospital for Sick Children Poison Information Centre (PIC) between January 1st and July 31st 2002 were reviewed. Patients with valproic acid… CONTINUE READING
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