Extracorporeal elimination in acute valproic acid poisoning

  title={Extracorporeal elimination in acute valproic acid poisoning},
  author={R. Thanacoody},
  journal={Clinical Toxicology},
  pages={609 - 616}
  • R. Thanacoody
  • Published 2009
  • Medicine
  • Clinical Toxicology
  • Introduction. Valproic acid (VPA) is an antiepileptic drug that is now used for a variety of neurological and psychiatric indications. Clinical manifestations of severe VPA poisoning include central nervous system depression, hypotension, electrolyte and acid–base disturbances, and hyperammonemia. Although extracorporeal methods have been used to enhance VPA elimination, the indications for and effectiveness of these methods have not been fully characterized. Methods. A systematic literature… CONTINUE READING
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