Extracorporeal elimination in acute valproic acid poisoning

@article{Thanacoody2009ExtracorporealEI,
  title={Extracorporeal elimination in acute valproic acid poisoning},
  author={R. Thanacoody},
  journal={Clinical Toxicology},
  year={2009},
  volume={47},
  pages={609 - 616}
}
  • R. Thanacoody
  • Published 2009
  • Medicine
  • Clinical Toxicology
  • Introduction. Valproic acid (VPA) is an antiepileptic drug that is now used for a variety of neurological and psychiatric indications. Clinical manifestations of severe VPA poisoning include central nervous system depression, hypotension, electrolyte and acid–base disturbances, and hyperammonemia. Although extracorporeal methods have been used to enhance VPA elimination, the indications for and effectiveness of these methods have not been fully characterized. Methods. A systematic literature… CONTINUE READING
    33 Citations
    Severe valproate induced hyperammonemic encephalopathy successfully managed with peritoneal dialysis
    • A. Kumar, A. Suri, B. Sharma
    • Medicine
    • Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
    • 2014
    • 7
    Favorable results after conservative management of 316 valproate intoxicated patients
    • S. Shadnia, H. Amiri, +4 authors N. Zamani
    • Medicine
    • Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
    • 2015
    • 7
    • PDF
    Valproic Acid Overdose Review of a Case With Electrocardiographic Changes.
    • A. Muñiz
    • Medicine
    • The Journal of emergency medicine
    • 2017
    Extracorporeal Treatments for Poisoning : Overview and Limitations
    • 1
    • PDF
    Drug-induced hyperlactatemia
    • 12
    • PDF

    References

    SHOWING 1-10 OF 50 REFERENCES
    [Hemoperfusion in the treatment of acute valproic acid intoxication].
    • 7
    Effectiveness of haemofiltration in valproic acid intoxication
    • 10
    • Highly Influential
    Successful Use of Hemodialysis in Acute Valproic Acid Intoxication
    • 9
    • Highly Influential
    Extracorporeal removal of toxic valproic acid levels in children
    • 17
    • Highly Influential
    Extracorporeal Management of Valproic Acid Toxicity: A Case Report and Review of the Literature
    • 38
    • Highly Influential
    A case of hemoperfusion and L-carnitine management in valproic acid overdose.
    • 18
    Severe valproic acid intoxication: case study on the unbound fraction and the applicability of extracorporeal elimination
    • 12
    • Highly Influential
    Valproic Acid Toxicity: Overview and Management
    • 177
    • Highly Influential
    Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning.
    • 23
    • Highly Influential
    Valproic acid toxicokinetics: serial hemodialysis and hemoperfusion.
    • 55
    • Highly Influential