Extracorporeal Shock Wave Rebuilt Subchondral Bone In Vivo and Activated Wnt5a/Ca2+ Signaling In Vitro

@inproceedings{Yu2017ExtracorporealSW,
  title={Extracorporeal Shock Wave Rebuilt Subchondral Bone In Vivo and Activated Wnt5a/Ca2+ Signaling In Vitro},
  author={Lai Yu and Shuitao Liu and Zhe Zhao and Lin Xia and Haochong Zhang and Jing Lou and Jun Yang and Gengmei Xing and Gengyan Xing},
  booktitle={BioMed research international},
  year={2017}
}
Background This study aimed to identify the optimal extracorporeal shock wave (ESW) intensity and to investigate its effect on subchondral bone rebuilt in vivo and Wnt5a/Ca2+ signaling in vitro using an osteoarthritis (OA) rat model and bone marrow mesenchymal stem cells (BMMSCs), respectively. Methods OA rats treated with (OA + ESW group) or without (OA group) ESW (n = 12/group) were compared with healthy controls (control group, n = 12). Gait patterns and subchondral trabecular bone changes… CONTINUE READING