Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome

@article{Combes2018ExtracorporealMO,
  title={Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome},
  author={Alain Combes and David Hajage and G. Capellier and Alexandre Demoule and Sylvain Lavoué and Christophe Guervilly and Daniel da Silva and Lara Zafrani and Patrice Tirot and Benoit Veber and Eric Maury and Bruno Levy and Yves Cohen and Christian Richard and Pierre Kalfon and Lila Bouadma and Hossein Mehdaoui and G. Beduneau and Guillaume Lebreton and Laurent J. Brochard and Niall D. Ferguson and Eddy Fan and Arthur S. Slutsky and Daniel Brodie and Alain Mercat},
  journal={The New England Journal of Medicine},
  year={2018},
  volume={378},
  pages={1965–1975}
}
BACKGROUND The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial. METHODS In an international clinical trial, we randomly assigned patients with very severe ARDS, as indicated by one of three criteria — a ratio of partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) of less than 50 mm Hg for more than 3 hours; a Pao2:Fio2 of less than 80 mm Hg for more than 6… 

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