Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity

  title={Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity},
  author={Kristen M. Turner and Viraj Deshpande and Doruk Beyter and Tomoyuki Koga and Jessica M. Rusert and Catherine Lee and Bin Li and Karen C. Arden and Bing Ren and David A. Nathanson and Harley Ian Kornblum and Michael D. Taylor and Sharmeela Kaushal and Webster K Cavenee and Robert J Wechsler-Reya and Frank B Furnari and Scott R. Vandenberg and P. Nagesh Rao and Geoffrey M. Wahl and Vineet Bafna and Paul Mischel},
Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood. We performed whole-genome sequencing, structural modelling and cytogenetic analyses of 17 different cancer types, including analysis of the structure and function of chromosomes during metaphase of 2,572 dividing cells, and developed a software package called… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 342 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
29 Citations
33 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 29 extracted citations


Publications referenced by this paper.
Showing 1-10 of 33 references

Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer

  • F. Mitelman, B. Johansson, F. Mertens
  • <http://cgap.nci.nih.gov/Chromosomes/Mitelman>
  • 2016

Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett’s esophagus

  • X Li
  • Cancer Prev Res (Phila)
  • 2014

Similar Papers

Loading similar papers…