Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity

@inproceedings{Turner2017ExtrachromosomalOA,
  title={Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity},
  author={Kristen M. Turner and Viraj Deshpande and Doruk Beyter and Tomoyuki Koga and Jessica M. Rusert and Catherine Lee and Bin Li and Karen C. Arden and Bing Ren and David A. Nathanson and Harley Ian Kornblum and Michael D. Taylor and Sharmeela Kaushal and Webster K Cavenee and Robert J Wechsler-Reya and Frank B Furnari and Scott R. Vandenberg and P. Nagesh Rao and Geoffrey M. Wahl and Vineet Bafna and Paul Mischel},
  booktitle={Nature},
  year={2017}
}
Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood. We performed whole-genome sequencing, structural modelling and cytogenetic analyses of 17 different cancer types, including analysis of the structure and function of chromosomes during metaphase of 2,572 dividing cells, and developed a software package called… CONTINUE READING
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