Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci.

@article{Gibaud2010ExtrachromosomalAM,
  title={Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci.},
  author={Anne Gibaud and Nicolas Vogt and Nabila-Sandra Hadj-Hamou and Jean-Philippe Meyniel and Philippe Hup{\'e} and Michelle Debatisse and Bernard Malfoy},
  journal={Human molecular genetics},
  year={2010},
  volume={19 7},
  pages={1276-85}
}
Accumulation of extrachromosomal DNA molecules (double minute) is often responsible for gene amplification in cancers, but the mechanisms leading to their formation are still largely unknown. By using quantitative PCR, chromosome walking, in situ hybridization on metaphase chromosomes and whole genome analysis, we studied a glioma containing four extrachromosomally amplified loci (7p11, 1q32.1, 5p15 and 9p2). Complex extrachromosomal DNA molecules were formed by the fusion of several syntenic… CONTINUE READING

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