• Biology, Medicine
  • Published in
    The Journal of clinical…
    1998
  • DOI:10.1172/jci1614

Extracellularly occurring histone H1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages.

@article{Brix1998ExtracellularlyOH,
  title={Extracellularly occurring histone H1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages.},
  author={Klaudia Brix and W Summa and Friedrich Lottspeich and Volker Herzog},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 2},
  pages={
          283-93
        }
}
Thyroglobulin is the major secretory protein of thyroid epithelial cells. Part of thyroglobulin reaches the circulation of vertebrates by transcytosis across the epithelial wall of thyroid follicles. Clearance of thyroglobulin from the circulation occurs within the liver via internalization of thyroglobulin by macrophages. Here we have analyzed the interaction of thyroglobulin with the cell surface of J774 macrophages with the aim to identify the possible thyroglobulin-binding sites on… CONTINUE READING

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