Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery.

@article{Gullotti2009ExtracellularlyAN,
  title={Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery.},
  author={Emily Gullotti and Yoon Yeo},
  journal={Molecular pharmaceutics},
  year={2009},
  volume={6 4},
  pages={1041-51}
}
One of the main goals of nanomedicine is to develop a nanocarrier that can selectively deliver anticancer drugs to the targeted tumors. Extensive efforts have resulted in several tumor-targeted nanocarriers, some of which are approved for clinical use. Most nanocarriers achieve tumor-selective accumulation through the enhanced permeability and retention effect. Targeting molecules such as antibodies, peptides, ligands, or nucleic acids attached to the nanocarriers further enhance their… CONTINUE READING

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