Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice

@inproceedings{Rajendran2017ExtracellularVD,
  title={Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice},
  author={Ramya Lakshmi Rajendran and Prakash Gangadaran and Soon Sun Bak and Ji Min Oh and Senthil Kumar Kalimuthu and Ho Won Lee and Se hwan Baek and Liya Zhu and Young Kwan Sung and Shin Young Jeong and Sang-Woo Lee and Jaetae Lee and Byeong-Cheol Ahn},
  booktitle={Scientific Reports},
  year={2017}
}
Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model. MSC-EV treatment increased DP cell proliferation and migration, and elevated the levels of Bcl-2, phosphorylated Akt and ERK. In addition; DP… CONTINUE READING
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