Extracellular ubiquitin: immune modulator and endogenous opponent of damage‐associated molecular pattern molecules

@article{Majetschak2011ExtracellularUI,
  title={Extracellular ubiquitin: immune modulator and endogenous opponent of damage‐associated molecular pattern molecules},
  author={Matthias Majetschak},
  journal={Journal of Leukocyte Biology},
  year={2011},
  volume={89}
}
  • M. Majetschak
  • Published 1 February 2011
  • Biology
  • Journal of Leukocyte Biology
Ubiquitin is a post‐translational protein modifier and plays essential roles in all aspects of biology. Although the discovery of ubiquitin introduced this highly conserved protein as a molecule with extracellular actions, the identification of ubiquitin as the ATP‐dependent proteolysis factor 1 has focused subsequent research on its important intracellular functions. Little attention has since been paid to its role outside of the cell. During recent years, multiple observations suggest that… 
An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors.
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The findings suggest that the structural determinants of the CXCR4 agonist activity of ubiquitin mimic the typical structure-function relationship of chemokines.
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Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3 Ubiquitin Ligases
TLDR
The identification of the arachnid HDP oligoventin, which shares homology to a core member of the UPP, E3 ubiquitin ligases, and compares the production of HDPs and endogenous antigens from orthologous HECT E3s by proteasomal degradation as a means of analyzing the U PP coupling to metazoan immunity.
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