Extracellular ubiquitin: immune modulator and endogenous opponent of damage‐associated molecular pattern molecules

@article{Majetschak2011ExtracellularUI,
  title={Extracellular ubiquitin: immune modulator and endogenous opponent of damage‐associated molecular pattern molecules},
  author={Matthias Majetschak},
  journal={Journal of Leukocyte Biology},
  year={2011},
  volume={89}
}
  • M. Majetschak
  • Published 1 February 2011
  • Biology
  • Journal of Leukocyte Biology
Ubiquitin is a post‐translational protein modifier and plays essential roles in all aspects of biology. Although the discovery of ubiquitin introduced this highly conserved protein as a molecule with extracellular actions, the identification of ubiquitin as the ATP‐dependent proteolysis factor 1 has focused subsequent research on its important intracellular functions. Little attention has since been paid to its role outside of the cell. During recent years, multiple observations suggest that… 
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89 Citations

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An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors.
Advantages of Extracellular Ubiquitin in Modulation of Immune Responses
TLDR
Recent observations showed that it can suppress immune response and prevent inflammation, and may provide good potential as a new tool for targeted therapy for immune mediated disorders of various etiologies.
Extracellular Ubiquitin: Role in Myocyte Apoptosis and Myocardial Remodeling.
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The role of extracellular UB in cardiac myocyte apoptosis and myocardial remodeling is summarized and covalent linkage of UB to a variety of cellular proteins (ubiquitination) is one of the most common posttranslational modifications in eukaryotic cells.
Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification.
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It is shown that C-terminal truncated Ubiquitin antagonizes ubiquitin and stromal cell-derived factor (SDF)-1α induced effects on cell signaling and function and that the development of CXCR4 ligands with enhanced agonist activities is possible.
HIV‐1, ubiquitin and ubiquitin‐like proteins: the dialectic interactions of a virus with a sophisticated network of post‐translational modifications
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The aim of this review is to provide an overview on the intricate and conflicting relationships that intimately link HIV‐1 and these sophisticated systems of post‐translational modifications.
A novel immunosuppressory peptide originating from the ubiquitin sequence
Structural Determinants of Ubiquitin-CXC Chemokine Receptor 4 Interaction*
TLDR
The findings suggest that the structural determinants of the CXCR4 agonist activity of ubiquitin mimic the typical structure-function relationship of chemokines.
Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties
Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.
Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3 Ubiquitin Ligases
TLDR
The identification of the arachnid HDP oligoventin, which shares homology to a core member of the UPP, E3 ubiquitin ligases, and compares the production of HDPs and endogenous antigens from orthologous HECT E3s by proteasomal degradation as a means of analyzing the U PP coupling to metazoan immunity.
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References

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