Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress.

@article{Bearden2010ExtracellularTG,
  title={Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress.},
  author={Shawn E. Bearden and Richard S. Beard and Jean C Pfau},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 5},
  pages={H1568-76}
}
Homocysteine, a cardiovascular and neurocognitive disease risk factor, is converted to hydrogen sulfide, a cardiovascular and neuronal protectant, through the transsulfuration pathway. Given the damaging effects of free homocysteine in the blood and the importance of blood homocysteine concentration as a prognosticator of disease, we tested the hypotheses that the blood itself regulates homocysteine-hydrogen sulfide metabolism through transsulfuration and that transsulfuration capacity and… CONTINUE READING
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Chronic diet-induced hyperhomocysteinemia impairs eNOS H1575 TRANSSULFURATION IN BLOOD AJP-Heart

  • RC Looft-Wilson, BS Ashley, JE Billig, MR Wolfert, LA Ambrecht, SE. Bearden
  • Circ Physiol
  • 2010
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