Extracellular transport of VirG protein in Shigella.

  title={Extracellular transport of VirG protein in Shigella.},
  author={Tsutomu Suzuki and M C Lett and Chihiro Sasakawa},
  journal={The Journal of biological chemistry},
  volume={270 52},
The ability of Shigella to spread within and between epithelial cells is a prerequisite for causing bacillary dysentery and requires the function encoded by the virG gene on the large plasmid. The outer membrane VirG (IcsA) protein is essential for bacterial spreading by eliciting polar deposition of filamentous actin (F-actin) in the cytoplasm of epithelial cells. Recent studies have indicated that an N-terminal 80-kDa VirG portion is exposed on the bacterial cell surface and released into the… CONTINUE READING

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