Extracellular thioredoxin: a therapeutic tool to combat inflammation.

  title={Extracellular thioredoxin: a therapeutic tool to combat inflammation.},
  author={Yoshiyuki Matsuo and Junji Yodoi},
  journal={Cytokine & growth factor reviews},
  volume={24 4},
The manipulation of cellular redox status has emerged as a promising therapeutic strategy to prevent uncontrolled inflammatory response. Thioredoxin is an important regulator of cellular redox homeostasis, which catalyzes the reduction of disulfide bonds. Human thioredoxin, originally identified as a secretory protein ADF, has been implicated in a wide variety of redox regulations in both intracellular and extracellular compartments. This review includes a summary of the evidence available… CONTINUE READING

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