Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function.

@article{Ragnarsson2014ExtracellularSR,
  title={Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function.},
  author={Lotten Ragnarsson and {\AA}sa Andersson and Walter G Thomas and Richard James Lewis},
  journal={Molecular pharmacology},
  year={2014},
  volume={87 1},
  pages={
          121-9
        }
}
Ligand binding and conformational changes that accompany signaling from G protein-coupled receptors (GPCRs) have mostly focused on the role of transmembrane helices and intracellular loop regions. However, recent studies, including several GPCRs cocrystallized with bound ligands, suggest that the extracellular surface (ECS) of GPCRs plays an important role in ligand recognition, selectivity, and binding, as well as potentially contributing to receptor activation and signaling. This study… CONTINUE READING
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