Extracellular superoxide production by Enterococcus faecalis requires demethylmenaquinone and is attenuated by functional terminal quinol oxidases

@article{Huycke2001ExtracellularSP,
  title={Extracellular superoxide production by Enterococcus faecalis requires demethylmenaquinone and is attenuated by functional terminal quinol oxidases},
  author={M. Huycke and D. Moore and W. Joyce and P. Wise and L. Shepard and Y. Kotake and M. Gilmore},
  journal={Molecular Microbiology},
  year={2001},
  volume={42}
}
The intestinal commensal bacterium, Enterococcus faecalis, is unusual among prokaryotic organisms in its ability to produce substantial extracellular superoxide. Transposon mutagenesis, allelic replacement, and electron spin resonance (ESR)‐spin trapping showed that superoxide production and generation of derivative hydroxyl radical were dependent on membrane‐associated demethylmenaquinone. Extracellular superoxide was generated through univalent reduction of oxygen by reduced… Expand
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