Extracellular superoxide dismutase and cardiovascular disease.

@article{Fukai2002ExtracellularSD,
  title={Extracellular superoxide dismutase and cardiovascular disease.},
  author={Tohru Fukai and R. J. Folz and Ulf Landmesser and David G Harrison},
  journal={Cardiovascular research},
  year={2002},
  volume={55 2},
  pages={239-49}
}
Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O(2)(*-)), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O(2)(*-) are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 131 extracted citations

Adenovirus-Mediated Prothymosin α Gene Transfer Inhibits the Development of Atherosclerosis in Apoe-Deficient Mice

M Chang, Y. Yang, +4 authors C L Wu
International journal of biological sciences • 2014
View 4 Excerpts
Highly Influenced

Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie • 2011
View 4 Excerpts
Highly Influenced

Impact of Superoxide Dismutase on Nitric Oxide and Peroxynitrite Levels in the Microcirculation - A Computational Model

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society • 2007
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…