Extracellular superoxide dismutase and cardiovascular disease.

  title={Extracellular superoxide dismutase and cardiovascular disease.},
  author={Tohru Fukai and R. J. Folz and Ulf Landmesser and David G Harrison},
  journal={Cardiovascular research},
  volume={55 2},
Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O(2)(*-)), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O(2)(*-) are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a… CONTINUE READING


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