Extracellular superoxide dismutase (EC-SOD) gene mutations screening in a sample of Mediterranean population.

@article{Campo2005ExtracellularSD,
  title={Extracellular superoxide dismutase (EC-SOD) gene mutations screening in a sample of Mediterranean population.},
  author={Salvatore Campo and Adriana M Sardo and Giuseppe Maurizio Campo and Angela D'Ascola and Angela Avenoso and Maria Castaldo and Carlo Saitta and Amalia Lania and Antonino Saitta and Alberto Calatroni},
  journal={Mutation research},
  year={2005},
  volume={578 1-2},
  pages={143-8}
}
The main role of superoxide dismutases (SODs) is to eliminate reactive oxygen species in cells and tissues. Extracellular SOD (EC-SOD/SOD3) is a major superoxide scavenger and it is located on cell surfaces and primarily in extracellular matrix, and binds heparan sulfates by its carboxyterminal portion. Human EC-SOD gene is located on chromosome 4 and comprises three exons and two introns. The SOD3 coding sequence is entirely located within exon 3 and has missense polymorphisms. The Arg213Gly… CONTINUE READING