Extracellular signal-regulated protein kinase, but not c-Jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation.

@article{Kim2005ExtracellularSP,
  title={Extracellular signal-regulated protein kinase, but not c-Jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation.},
  author={K I Kim and Kyung-Chul Choi and Se-Hyung Park and Nelly Auersperg and Peter C. K. Leung},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 3},
  pages={1670-7}
}
Although a novel second form of GnRH (GnRH-II) has been reported to have an antiproliferative effect on gynecologic cancer cells, its biological mechanism remains to be elucidated. We have previously demonstrated that GnRH-II activates p38 MAPK. There is accumulating evidence that activation of MAPKs by GnRH-I and -II is important for cell proliferation, differentiation, and apoptosis. In the present study, we further investigated the involvement of GnRH-II in the inhibition of cell… CONTINUE READING