Extracellular signal-regulated kinase phosphorylation due to menadione-induced arylation mediates growth inhibition of pancreas cancer cells

Abstract

Cytotoxicity of Vitamin K3 (VK3) is indicated to have the same mechanism with oxidative stress (H2O2). In the present study, we analyzed the differences and/or similarities in the cellular responses to oxidative stress and VK3 to clarify the mechanism of growth inhibition. Cell viability was determined by a test method with 3-[4, 5-dimethyl-thiazol]-2, 5… (More)
DOI: 10.1007/s00280-007-0610-9

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@article{Osada2007ExtracellularSK, title={Extracellular signal-regulated kinase phosphorylation due to menadione-induced arylation mediates growth inhibition of pancreas cancer cells}, author={Shinji Osada and Fumio Sakashita and Yosiki Hosono and Kenichi Nonaka and Yasuharu Tokuyama and Hidenori Tanaka and Yoshiyuki Sasaki and Hiroyuki Tomita and Shuji Komori and Satoshi Matsui and Takao Takahashi}, journal={Cancer Chemotherapy and Pharmacology}, year={2007}, volume={62}, pages={315-320} }