Extracellular signal-regulated kinase-mammalian target of rapamycin signaling and forkhead-box transcription factor 3a phosphorylation are involved in testosterone's effect on severe burn injury in a rat model.

@article{Ma2015ExtracellularSK,
  title={Extracellular signal-regulated kinase-mammalian target of rapamycin signaling and forkhead-box transcription factor 3a phosphorylation are involved in testosterone's effect on severe burn injury in a rat model.},
  author={Li Ma and Chuan-an Shen and Jiake Chai and Huinan Yin and Huping Deng and Rui Feng},
  journal={Shock},
  year={2015},
  volume={43 1},
  pages={
          85-91
        }
}
BACKGROUND Testosterone and androgen receptor agonists have been known for a long time to prevent or reverse muscle wasting in burn injury patients, but the exact molecular mechanisms are not clear. OBJECTIVE To investigate the underlying molecular mechanisms of testosterone in severely burned rats. METHODS Severe burn injuries were induced by immersing the back of the rat in 100 °C water for 12 s. Rats were treated for 14 days with vehicle (burn group) or a physiological replacement dose… CONTINUE READING
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