Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.

@article{Omori2006ExtracellularSK,
  title={Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.},
  author={Sayu Omori and Mariko Hida and Hisayo Fujita and Hisahide Takahashi and Susumu Tanimura and Michiaki Kohno and Midori Awazu},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 6},
  pages={1604-14}
}
The expression of mitogen-activated protein kinases (MAPK) in DBA/2-pcy/pcy (pcy) mice, a murine model of polycystic kidney disease was investigated. Proliferating cell nuclear antigen-positive cells were recognized in cyst epithelium from embryonic day 14.5 to 25 wk of age. Extracellular signal-regulated kinase (ERK) was expressed in the renal tubules of control and pcy mice, but stronger immunostaining was observed in cyst epithelium. Phosphorylated ERK was detected only in pcy mice and was… CONTINUE READING

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