Extracellular signal-regulated kinase and c-Jun N-terminal protein kinase in ischemic tolerance.

@article{Gu2001ExtracellularSK,
  title={Extracellular signal-regulated kinase and c-Jun N-terminal protein kinase in ischemic tolerance.},
  author={Zhi-Yuan Gu and Qian Jiang and Guang-yi Zhang},
  journal={Neuroreport},
  year={2001},
  volume={12 16},
  pages={
          3487-91
        }
}
The alterations and involvement of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal protein kinase (JNK) activation were examined in the hippocampal CA1 region in a rat model of global brain ischemic tolerance. Western blotting study showed that ERK activation (diphosphorylation) level was decreased (3.75-, 0.56-, and 0.23-fold vs sham control) and JNK activation level was increased (3.82-, 4.63-, and 5.30-fold vs sham control) 3 days after more severe ischemic insults (6 min, 8… CONTINUE READING

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