Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27

@article{Boer2004ExtracellularSR,
  title={Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27},
  author={Rudolf A. de Boer and Saraswati Pokharel and Markus Flesch and Derk A. van Kampen and Albert J Suurmeijer and Frans Boomsma and Wiek H. van Gilst and Dirk Jan van Veldhuisen and Yigal M. Pinto},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={82},
  pages={678-687}
}
Angiotensin (Ang) II is a key player in left ventricular (LV) remodeling and cardiac fibrosis. Its effects are thought to be transferred at least in part by mitogen-activated protein kinases (MAPK), transforming growth factor (TGF) β1, and the Smad pathway. In this study we sought to elucidate whether Ang II related effects on LV dysfunction and fibrosis in vivo are mediated via MAPK or rather via Smad stimulation. We treated homozygous REN2 rats (7–11 weeks) with placebo, Ang II type 1 (AT1… CONTINUE READING

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