Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro.

@article{Xiao2012ExtracellularSK,
  title={Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro.},
  author={Junhua Xiao and Anita H Ferner and Agnes W. Wong and Mark Denham and Trevor J. Kilpatrick and Simon S Murray},
  journal={Journal of neurochemistry},
  year={2012},
  volume={122 6},
  pages={
          1167-80
        }
}
Multiple extracellular factors have been implicated in orchestrating myelination of the CNS; however, less is known about the intracellular signaling cascades that regulate this process. We have previously shown that brain-derived neurotrophic factor (BDNF) promotes oligodendrocyte myelination. Here, we screened for the activation of candidate signaling pathways in in vitro myelination assays and found that extracellular signal-regulated kinase (Erk) signaling positively correlated with basal… CONTINUE READING

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