Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression.

@article{Yang2006ExtracellularSK,
  title={Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression.},
  author={Wei Yang and Yan Chen and Yong Zhang and Xueyan Wang and Ning Yang and Dahai Zhu},
  journal={Cancer research},
  year={2006},
  volume={66 3},
  pages={1320-6}
}
The cytokines of transforming growth factor beta (TGF-beta) and its superfamily members are potent regulators of tumorigenesis and multiple cellular events. Myostatin is a member of TGF-beta superfamily and plays a negative role in the control of cell proliferation and differentiation. We now show that myostatin rapidly activated the extracellular signal-regulated kinase 1/2 (Erk1/2) cascade in C2C12 myoblasts. A more remarkable Erk1/2 activation stimulated by myostatin was observed in… CONTINUE READING
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