Extracellular secretion of the virulence plasmid-encoded ADP-ribosyltransferase SpvB in Salmonella.

@article{Gotoh2003ExtracellularSO,
  title={Extracellular secretion of the virulence plasmid-encoded ADP-ribosyltransferase SpvB in Salmonella.},
  author={Hideo Gotoh and Nobuhiko Okada and Yun Gi Kim and Kouya Shiraishi and Naoko Hirami and Takeshi Haneda and Ai Kurita and Yuji Kikuchi and Hirofumi Danbara},
  journal={Microbial pathogenesis},
  year={2003},
  volume={34 5},
  pages={227-38}
}
Nontyphoid Salmonella enterica requires the plasmid-encoded spv genes to establish successful systemic infection in experimental animals. The SpvB virulence-associated protein has recently been shown to contain the ADP-ribosyltransferase domain. SpvB ADP-ribosilates actin and depolymerizes actin filaments when expressed in cultured epithelial cells. However, spontaneous secretion or release of SpvB has not been observed under in vitro growth conditions. In the present study we investigated the… CONTINUE READING