Extracellular regulation of TGF-beta activity in wound repair: growth factor latency as a sensor mechanism for injury.

@article{Brunner2004ExtracellularRO,
  title={Extracellular regulation of TGF-beta activity in wound repair: growth factor latency as a sensor mechanism for injury.},
  author={Georg Brunner and Robert Blakytny},
  journal={Thrombosis and haemostasis},
  year={2004},
  volume={92 2},
  pages={253-61}
}
The transforming growth factor-beta (TGFbeta) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGFbeta biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the cellular microenvironment. Targeting and mobilization, and particularly extracellular activation of latent TGF-beta control the biological action of this growth factor. This… CONTINUE READING