Extracellular redox state shift: A novel approach to target prostate cancer invasion.

@article{Zhong2018ExtracellularRS,
  title={Extracellular redox state shift: A novel approach to target prostate cancer invasion.},
  author={Weixiong Zhong and Heidi L. Weiss and Rani D Jayswal and Patrick J. Hensley and Laura M Downes and Daret K. St. Clair and Luksana Chaiswing},
  journal={Free radical biology & medicine},
  year={2018},
  volume={117},
  pages={
          99-109
        }
}
AIM Extracellular superoxide dismutase (ECSOD) and the cysteine/glutamate transporter (Cys)/(xCT) are tumor microenvironment (TME) redox state homeostasis regulators. Altered expression of ECSOD and xCT can lead to imbalance of the TME redox state and likely have a profound effect on cancer invasion. In the present study, we investigated whether ECSOD and xCT could be therapeutic targets for prostate cancer (PCa) invasion. RESULTS Immunohistochemistry of tumor microarray PCa tissues (N = 165… CONTINUE READING
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