Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus.

@article{Mart2010ExtracellularPI,
  title={Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus.},
  author={Miguel Mart{\'i} and Mar{\'i}a Pilar Trotonda and Mar{\'i}a Angeles Tormo-M{\'a}s and Marta Vergara-Irigaray and Ambrose L. Cheung and I{\~n}igo Lasa and Jos{\'e} R Penad{\'e}s},
  journal={Microbes and infection},
  year={2010},
  volume={12 1},
  pages={55-64}
}
In Staphylococcus aureus, biofilm formation can be associated with the production of surface-anchored proteins, including Bap, SasG, FnBPs or Spa. By mutational analysis, and using a model strain in which biofilm formation was Bap-dependent, we found that sigma(B) was essential for protein-dependent biofilm development. Non-polar mutations of sigma(B) in genetically unrelated S. aureus strains lowered the Bap expression and completely impaired biofilm development. Although Northern blot… CONTINUE READING

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