• Biology, Medicine
  • Published in Journal of lipid research 1995

Extracellular processing of phospholipids is required for permeability barrier homeostasis.

@article{Maoqiang1995ExtracellularPO,
  title={Extracellular processing of phospholipids is required for permeability barrier homeostasis.},
  author={Man Mao-qiang and Kenneth R. Feingold and M Jain and Peter M Elias},
  journal={Journal of lipid research},
  year={1995},
  volume={36 9},
  pages={
          1925-35
        }
}
Three key lipid types, cholesterol, ceramides (CER), and free fatty acids (FA), form the stratum corneum (SC) lamellar bilayers that mediate barrier function. Prior studies have shown that barrier requirements regulate CER generation from glucosylCER, and that this catabolic step takes place within the SC interstices. Here, we addressed whether extracellular processing of phospholipids (PL), the FA precursor delivered to the SC interstices with glucosylCER and cholesterol during exocytosis of… CONTINUE READING

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