Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor.

@article{Wihlborg2003ExtracellularNI,
  title={Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor.},
  author={Anna-Karin Wihlborg and Malin Malmsj{\"o} and Atli Eyjolfsson and R. T. Gustafsson and Kenneth A. Jacobson and David Erlinge},
  journal={British journal of pharmacology},
  year={2003},
  volume={138 8},
  pages={1451-8}
}
1. The present study was aimed at examining P2 receptor-mediated vasodilatation in human vessels. The isometric tension was recorded in isolated segments of the human left internal mammary artery branches precontracted with 1 microM noradrenaline. 2. Endothelial denudation abolished the dilator responses. 3. The selective P2Y(1) agonist, 2-MeSADP, induced a potent vasodilatation (pEC(50)=6.9+/-0.1). The P2Y(1) antagonist of 10 microM, MRS 2216, shifted the 2-MeSADP concentration-response curve… CONTINUE READING