Extracellular nucleoside diphosphate kinase NM23/NDPK modulates normal hematopoietic differentiation.

@article{Willems2002ExtracellularND,
  title={Extracellular nucleoside diphosphate kinase NM23/NDPK modulates normal hematopoietic differentiation.},
  author={Roel Willems and Herman Slegers and Inez E R Rodrigus and Adriaan C Moulijn and Marc Lenjou and Griet Nijs and Zwi Nisan Berneman and Dirk R van Bockstaele},
  journal={Experimental hematology},
  year={2002},
  volume={30 7},
  pages={640-8}
}
OBJECTIVE We previously demonstrated the presence of nucleoside diphosphate kinase NDPK/NM23 in normal human plasma. It also was reported that extracellular NM23 could inhibit differentiation of certain hematopoietic cell lines. We further investigated the extracellular effect of NM23 on hematopoiesis by adding recombinant NM23-H1, NM23-H2, and NM23-H3 proteins to in vitro differentiation assays of normal human hematopoietic progenitors. MATERIALS AND METHODS To study the effect on the… CONTINUE READING

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