Extracellular mutant mitochondrial DNA content is dramatically elevated in the blood plasma of irradiated mice

@article{Abdullaev2009ExtracellularMM,
  title={Extracellular mutant mitochondrial DNA content is dramatically elevated in the blood plasma of irradiated mice},
  author={Serazhutdin A Abdullaev and Valeriya N Antipova and Azhub I. Gaziev},
  journal={Molecular Biology},
  year={2009},
  volume={43},
  pages={990-996}
}
Nucleic acids circulating in blood plasma and other biological fluids are of interest as potential markers for the diagnosis of various pathologies and the monitoring of stresses. Mitochondrial DNA (mtDNA) is a more vulnerable target for many genotoxic agents than nuclear DNA, and mutations in the mitochondrial genome can serve as markers for many diseases… CONTINUE READING