Extracellular metabolites of 2-aminofluorene in cultures of rapid and slow acetylator rabbit hepatocytes as a model for urinary and biliary metabolism.

@article{Mcqueen1988ExtracellularMO,
  title={Extracellular metabolites of 2-aminofluorene in cultures of rapid and slow acetylator rabbit hepatocytes as a model for urinary and biliary metabolism.},
  author={Charlene A. Mcqueen and M J Miller and B M Way and G. M. Williams},
  journal={Chemico-biological interactions},
  year={1988},
  volume={66 1-2},
  pages={
          71-83
        }
}
2 Citations
MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
A new international project to evaluate the relevance for human systemic and local toxicity of in vitro tests of general toxicity of chemicals has been organized by the Scandinavian Society of Cell

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The balance between activation and detoxification reactions of AAF in hepatocytes may be expressed as the ratio between covalently bound metabolites and the sum of C-hydroxylated and stable water-soluble metabolites, which correlated better with the species susceptibility to liver cancer than covalent binding as such.
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The data indicate that deacetylation is the most important step in the mutagenic activation of N-hydroxy-2-acetylaminofluorene by mouse and rat liver and kidney fractions and that the arylnitrenium ion is the electrophilic species interacting with the bacterial DNA, resulting in the frameshift mutation.
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