Extracellular matrix specific protein fingerprints measured in serum can separate pancreatic cancer patients from healthy controls

Abstract

Pancreatic cancer (PC) is an aggressive disease with an urgent need for biomarkers. Hallmarks of PC include increased collagen deposition (desmoplasia) and increased matrix metalloproteinase (MMP) activity. The aim of this study was to investigate whether protein fingerprints of specific MMP-generated collagen fragments differentiate PC patients from… (More)
DOI: 10.1186/1471-2407-13-554

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