Extracellular matrix selectively modulates the response of mammary epithelial cells to different soluble signaling ligands.

@article{Lee1999ExtracellularMS,
  title={Extracellular matrix selectively modulates the response of mammary epithelial cells to different soluble signaling ligands.},
  author={Y J Lee and Charles H Streuli},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 32},
  pages={22401-8}
}
In adherent cells, cell-substratum interactions are essential for the propagation of some growth factor signaling events. However, it has not been resolved to what extent different types of extracellular matrix regulate the signals elicited by different soluble ligands. Our previous work has shown that prolactin signaling in mammary epithelium requires a specific cell interaction with the basement membrane and does not occur in cells plated on collagen I. We have now investigated whether the… CONTINUE READING

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