Extracellular matrix scaffold for cardiac repair.

@article{Robinson2005ExtracellularMS,
  title={Extracellular matrix scaffold for cardiac repair.},
  author={Keith Alan Robinson and Jinshen Li and Megumi Mathison and Alka A. Redkar and Jianhua Cui and Nicolas A. F. Chronos and Robert G. Matheny and Stephen F. Badylak},
  journal={Circulation},
  year={2005},
  volume={112 9 Suppl},
  pages={
          I135-43
        }
}
BACKGROUND Heart failure remains a significant problem. Tissue-engineered cardiac patches offer potential to treat severe heart failure. We studied an extracellular matrix scaffold for repairing the infarcted left ventricle. METHODS AND RESULTS Pigs (n=42) underwent left ventricular (LV) infarction. At 6 to 8 weeks, either 4-layer multilaminate urinary bladder-derived extracellular matrix or expanded polytetrafluoroethlyene (ePTFE) was implanted as full-thickness LV wall patch replacement. At… CONTINUE READING

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