Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region.

Abstract

Thrombospondins (TSPs) are an evolutionarily ancient family of extracellular calcium-binding glycoproteins. The five mammalian TSPs collectively have important roles in angiogenesis and vascular biology, synaptogenesis, wound repair and connective tissue organisation. Their complex functions relate to the multiple postsecretion fates of TSPs that can… (More)
DOI: 10.1242/jcs.021006

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