Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis

@article{Vlodavsky2004ExtracellularMG,
  title={Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis},
  author={I. Vlodavsky and G. Korner and R. Ishai-Michaeli and P. Bashkin and R. Bar-Shavit and Z. Fuks},
  journal={Cancer and Metastasis Reviews},
  year={2004},
  volume={9},
  pages={203-226}
}
  • I. Vlodavsky, G. Korner, +3 authors Z. Fuks
  • Published 2004
  • Biology, Medicine
  • Cancer and Metastasis Reviews
  • SummaryNeoplastic cells require an appropriate pericellular environment and new formation of stroma and blood vessels in order to constitute a soilid tumor. Tumor progression also involves degradation of various extracellular matrix (ECM) constituents. In this review we have focused on the possible involvement of ECM-resident growth factors and enzymes in neovascularization and cell invasion. We demonstrate that the pluripotent angiogenic factor, basic fibroblast growth factor (bFGF) is an ECM… CONTINUE READING
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