Extracellular matrix remodeling following myocardial injury.

  title={Extracellular matrix remodeling following myocardial injury.},
  author={Merry L Lindsey and Douglas L. Mann and Mark L. Entman and Francis G. Spinale},
  journal={Annals of medicine},
  volume={35 5},
While current therapeutic strategies restore blood flow to the ischemic myocardium and limit infarct size, adverse left ventricular (LV) remodeling that progresses to dysfunction remains a significant complication following myocardial infarction (MI). The extracellular matrix (ECM) is a key component in the remodeling process, and increases in collagen occur in the infarct area to replace necrotic myocytes and form a scar. The ECM is coupled to the cell through cell surface receptors, primary… CONTINUE READING
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