Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

Abstract

Human granzyme B (GrB) released from cytotoxic lymphocytes plays a key role in the induction of target cell apoptosis when internalized in the presence of perforin. Here we demonstrate that GrB also possesses a potent extracellular matrix remodeling activity. Both native and recombinant GrB caused detachment of immortalized and transformed cell lines… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.