Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells.

@article{Chan2006ExtracellularMR,
  title={Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells.},
  author={Vivien Chan and Janette K Burgess and Jonathan C. Ratoff and Brian J O'connor and Anne Greenough and Tak Hong Lee and Stuart J. Hirst},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={174 4},
  pages={379-85}
}
RATIONALE Altered airway smooth muscle (ASM) function and enrichment of the extracellular matrix (ECM) with fibronectin and collagen are key features of asthma. Previously, we have reported these ECM proteins enhance ASM synthetic function. OBJECTIVE We compared ASM cultured from endobronchial biopsies from subjects with and without asthma to assess if asthmatic cells were hypersecretory and determined whether the underlying mechanism involved autocrine ECM production. METHODS AND… CONTINUE READING

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