Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

  title={Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques},
  author={Sarah Raye Langley and Karin Willeit and Athanasios Didangelos and Ljubica Matic and Philipp Skroblin and Javier Barallobre-Barreiro and Mariette Lengquist and Gregor Rungger and Alexander N Kapustin and Ludmilla Kedenko and Chris Molenaar and Ruifang Lu and Temo Barwari and Gonca Suna and Xiaoke Yin and Bernhard Iglseder and Bernhard Paulweber and Peter Willeit and Joseph Shalhoub and Gerard Pasterkamp and Alun H. Davies and Claudia Monaco and Ulf Hedin and Catherine M. Shanahan and Johann Willeit and Stefan Kiechl and Manuel Mayr},
  journal={The Journal of Clinical Investigation},
  pages={1546 - 1560}
Introduction Recent findings have challenged the prevailing histology- or imaging-based definition of the vulnerable plaque. Methods To investigate molecular characteristics associated with clinical instability of atherosclerosis, we performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from symptomatic versus asymptomatic patients. The proteomics data were integrated with gene expression profiling and an… 

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