Extracellular matrix proteins protect human HT1080 cells against the antimigratory effect of doxorubicin.

@article{Fourr2008ExtracellularMP,
  title={Extracellular matrix proteins protect human HT1080 cells against the antimigratory effect of doxorubicin.},
  author={Nicolas Fourr{\'e} and Emilie Millerot-Serrurot and Roselyne Garnotel and Jean-Marie Zahm and No{\"e}l Bonnet and Jean Paul Millot and Pierre Jeannesson},
  journal={Cancer science},
  year={2008},
  volume={99 8},
  pages={
          1699-705
        }
}
In solid tumors, the cell microenvironment appears to be a key determinant in the emergence of drug resistance, a major obstacle to the successful use of antitumor drugs. Our aim was to determine whether type I collagen and fibronectin, proteins of the extracellular matrix, were able to influence the antimigratory properties induced by the antitumor drug doxorubicin. These properties were investigated at doxorubicin concentrations of 10 and 20 nM, which do not affect cell proliferation on a 24… CONTINUE READING
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